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Tapentadol is a prescription medication classified as an opioid analgesic. It works by acting on the mu-opioid receptors and inhibiting the reuptake of norepinephrine, which enhances pain relief. It Used to treat pain from injuries, surgery, or trauma. Tapentadol Prescribed for long-term pain conditions when other pain relievers are not effective. It Effective for musculoskeletal pain (like back pain and arthritis).Â